Development and Validation of HPLC-DAD and UHPLC-DAD Methods for the Simultaneous Determination of Guanylhydrazone Derivatives Employing a Factorial Design

Development and Validation of HPLC-DAD and UHPLC-DAD Methods for the Simultaneous Determination of Guanylhydrazone Derivatives Employing a Factorial Design

Guanylhydrazones are molecules with great pharmacological potential in various therapeutic areas, including antitumoral activity. Factorial design is an excellent tool in the optimization of a chromatographic method, because it is possible quickly change factors such as temperature, mobile phase com...

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Bibliographic Details
Main Authors: Wanessa Azevedo de Brito, Monique Gomes Dantas, Fernando Henrique Andrade Nogueira, Edeildo Ferreira da Silva-Júnior, João Xavier de Araújo-Júnior, Thiago Mendonça de Aquino, Êurica Adélia Nogueira Ribeiro, Lilian Grace da Silva Solon, Cícero Flávio Soares Aragão, Ana Paula Barreto Gomes
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Molecules
Subjects:
guanylhydrazones
factorial design
HPLC-DAD
UHPLC-DAD
method validation
Online Access:https://www.mdpi.com/1420-3049/22/9/1394

Internet

https://www.mdpi.com/1420-3049/22/9/1394

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