Leishmanicidal Activity of (+)-Phyllanthidine and the Phytochemical Profile of Margaritaria nobilis (Phyllanthaceae)

Leishmanicidal Activity of (+)-Phyllanthidine and the Phytochemical Profile of Margaritaria nobilis (Phyllanthaceae)

The effects of the Securinega alkaloid (+)-phyllanthidine on Leishmania (L.) amazonensis and the first chemical investigation of Margaritaria nobilis L.f. (Phyllanthaceae) are described. Treating the parasites with this alkaloid caused a dose-dependent reduction in promastigote growth of 67.68% (IC5...

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Bibliographic Details
Main Authors: Lienne S. Moraes, Marcio R. H. Donza, Ana Paula D. Rodrigues, Bruno J. M. Silva, Davi S. B. Brasil, Maria das Graças B. Zoghbi, Eloísa H. A. Andrade, Giselle M. S. P. Guilhon, Edilene O. Silva
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Molecules
Subjects:
Leishmania (L.) amazonensis
leishmanicidal activity
alkaloid (+)-phyllanthidine
Online Access:http://www.mdpi.com/1420-3049/20/12/19829

Internet

http://www.mdpi.com/1420-3049/20/12/19829

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