β-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1β Production

β-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1β Production

Dectin-1/CLEC7A is a pattern recognition receptor that recognizes β-1,3 glucans, and its stimulation initiates signaling events characterized by the production of inflammatory cytokines from human dendritic cells (DCs) required for antifungal immunity. β-glucans differ greatly in size, structure, an...

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Bibliographic Details
Main Authors: Matthew J. Elder, Steve J. Webster, Ronnie Chee, David L. Williams, J. S. Hill Gaston, Jane C. Goodall
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
dectin-1
β-glucan
IL-1β
dendritic cell
reactive oxygen species
phagocytosis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00791/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00791/full

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