Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice

Abstract Background TAR DNA binding protein 43 (TDP-43) is the main disease protein in most patients with amyotrophic lateral sclerosis (ALS) and about 50% of patients with frontotemporal dementia (FTD). TDP-43 pathology is not restricted to patients with missense mutations in TARDBP, the gene encod...

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Bibliographic Details
Main Authors: Sander Beel, Sarah Herdewyn, Raheem Fazal, Mathias De Decker, Matthieu Moisse, Wim Robberecht, Ludo Van Den Bosch, Philip Van Damme
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Molecular Neurodegeneration
Subjects:
Frontotemporal dementia
Amyotrophic lateral sclerosis
TDP-43
Progranulin
Online Access:http://link.springer.com/article/10.1186/s13024-018-0288-y

Internet

http://link.springer.com/article/10.1186/s13024-018-0288-y

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