Tyrosine Phosphoproteomics of Patient-Derived Xenografts Reveals Ephrin Type-B Receptor 4 Tyrosine Kinase as a Therapeutic Target in Pancreatic Cancer

Tyrosine Phosphoproteomics of Patient-Derived Xenografts Reveals Ephrin Type-B Receptor 4 Tyrosine Kinase as a Therapeutic Target in Pancreatic Cancer

Pancreatic ductal adenocarcinoma is a recalcitrant tumor with minimal response to conventional chemotherapeutic approaches. Oncogenic signaling by activated tyrosine kinases has been implicated in cancers resulting in activation of diverse effector signaling pathways. Thus, the discovery of aberrant...

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Bibliographic Details
Main Authors: Santosh Renuse, Vijay S. Madamsetty, Dong-Gi Mun, Anil K. Madugundu, Smrita Singh, Savita Udainiya, Kiran K. Mangalaparthi, Min-Sik Kim, Ren Liu, S. Ram Kumar, Valery Krasnoperov, Mark Truty, Rondell P. Graham, Parkash S. Gill, Debabrata Mukhopadhyay, Akhilesh Pandey
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
EphB4
receptor tyrosine kinase
targeted therapy
personalized medicine
Online Access:https://www.mdpi.com/2072-6694/13/14/3404

Internet

https://www.mdpi.com/2072-6694/13/14/3404

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