Microwave-Assisted Synthesis of Arene Ru(II) Complexes Induce Tumor Cell Apoptosis Through Selectively Binding and Stabilizing bcl-2 G-Quadruplex DNA

Microwave-Assisted Synthesis of Arene Ru(II) Complexes Induce Tumor Cell Apoptosis Through Selectively Binding and Stabilizing bcl-2 G-Quadruplex DNA

A series of arene Ru(II) complexes coordinated with phenanthroimidazole derivatives, [(η6-C6H6)Ru(l)Cl]Cl(1b L = p-ClPIP = 2-(4-Chlorophenyl)imidazole[4,5f] 1,10-phenanthroline; 2b L = m-ClPIP = 2-(3-Chlorophenyl)imidazole[4,5f] 1,10-phenanthroline; 3b L = p-NPIP = 2-(4-Nitrophenyl)imidazole[4,5f] 1...

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Bibliographic Details
Main Authors: Yanhua Chen, Qiong Wu, Xicheng Wang, Qiang Xie, Yunyun Tang, Yutao Lan, Shuangyan Zhang, Wenjie Mei
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Materials
Subjects:
arene Ru(II) complexes
microwave-assisted synthesis
apoptosis inducer
selective stabilizing
bcl-2 G-quadruplex DNA
Online Access:http://www.mdpi.com/1996-1944/9/5/386

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http://www.mdpi.com/1996-1944/9/5/386

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