Factors influencing the statistical power of complex data analysis protocols for molecular signature development from microarray data.

Factors influencing the statistical power of complex data analysis protocols for molecular signature development from microarray data.

Critical to the development of molecular signatures from microarray and other high-throughput data is testing the statistical significance of the produced signature in order to ensure its statistical reproducibility. While current best practices emphasize sufficiently powered univariate tests of dif...

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Bibliographic Details
Main Authors: Constantin F Aliferis, Alexander Statnikov, Ioannis Tsamardinos, Jonathan S Schildcrout, Bryan E Shepherd, Frank E Harrell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2654113?pdf=render

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http://europepmc.org/articles/PMC2654113?pdf=render

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