Endocannabinoid Signaling at Hypothalamic Steroidogenic Factor-1/Proopiomelanocortin Synapses Is Sex- and Diet-Sensitive

Endocannabinoid Signaling at Hypothalamic Steroidogenic Factor-1/Proopiomelanocortin Synapses Is Sex- and Diet-Sensitive

We tested the hypotheses that steroidogenic factor (SF)-1 neurons in the hypothalamic ventromedial nucleus (VMN) provide sexually disparate, endocannabinoid (EC)- and diet-sensitive glutamatergic input onto proopiomelanocortin (POMC) neurons. Electrophysiological recordings were performed in hypotha...

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Bibliographic Details
Main Authors: Carolina Fabelo, Jennifer Hernandez, Rachel Chang, Sakara Seng, Natalia Alicea, Sharon Tian, Kristie Conde, Edward J. Wagner
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
endocannabinoids
obesity
steroidogenic factor-1
sex differences
estradiol
proopiomelanocortin
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00214/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00214/full

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