MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion
DNA replication transforms cohesin rings dynamically associated with chromatin into the cohesive form to establish sister-chromatid cohesion. Here, we show that, in human cells, cohesin loading onto chromosomes during early S phase requires the replicative helicase MCM2–7 and the kinase DDK. Cohesin...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-04-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/33920 |