Novel MYO1D Missense Variant Identified Through Whole Exome Sequencing and Computational Biology Analysis Expands the Spectrum of Causal Genes of Laterality Defects

Novel MYO1D Missense Variant Identified Through Whole Exome Sequencing and Computational Biology Analysis Expands the Spectrum of Causal Genes of Laterality Defects

Laterality defects (LDs) or asymmetrically positioned organs are a group of rare developmental disorders caused by environmental and/or genetic factors. However, the exact molecular pathophysiology of LD is not yet fully characterised. In this context, studying Arab population presents an ideal oppo...

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Bibliographic Details
Main Authors: Rabab Said Alsafwani, Khalidah K. Nasser, Thoraia Shinawi, Babajan Banaganapalli, Hanan Abdelhalim ElSokary, Zhaher F. Zaher, Noor Ahmad Shaik, Gaser Abdelmohsen, Jumana Yousuf Al-Aama, Adam J. Shapiro, Osman O. Al-Radi, Ramu Elango, Turki Alahmadi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Medicine
Subjects:
laterality defects
whole exome sequencing
microfilament
gene expression
variant
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.724826/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.724826/full

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