A Unique SUMO-Interacting Motif of Trx2 Is Critical for Its Mitochondrial Presequence Processing and Anti-oxidant Activity

A Unique SUMO-Interacting Motif of Trx2 Is Critical for Its Mitochondrial Presequence Processing and Anti-oxidant Activity

ObjectiveMitochondrial thioredoxin 2 (Trx2) is a vital mitochondrial redox protein that mediates normal protein thiol reduction and provides electrons to peroxiredoxin 3 (Prx3) to scavenge H2O2 in mitochondria. It has been widely reported that Trx2 deletion in cells or mice generates massive reactiv...

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Bibliographic Details
Main Authors: Chaofei Chen, Kang Wang, Haifeng Zhang, Huanjiao Jenny Zhou, Yuxin Chen, Wang Min
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Physiology
Subjects:
thioredoxin-2
mitochondria
sumoylation
SUMO-interacting motif
senescence
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01089/full

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https://www.frontiersin.org/article/10.3389/fphys.2019.01089/full

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