Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1β and IL-18 secretion but not to pyroptosis.

Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1β and IL-18 secretion but not to pyroptosis.

Interleukin-1β (IL-1β) is important for host resistance against Mycobacterium tuberculosis (Mtb) infections. The response of the dendritic cell inflammasome during Mtb infections has not been investigated in detail.Here we show that Mtb infection of bone marrow-derived dendritic cells (BMDCs) induce...

Full description

Bibliographic Details
Main Authors: Hana Abdalla, Lalitha Srinivasan, Swati Shah, Katrin D Mayer-Barber, Alan Sher, Fayyaz S Sutterwala, Volker Briken
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3404059?pdf=render

Internet

http://europepmc.org/articles/PMC3404059?pdf=render

Similar Items