Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression.
The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. These proteins contain two related domains known as the chromo- and the chromoshadow-domain. The chromo-domain binds histone H3 tails methylated on lysine 9. However, in vivo and in vitro experiments have...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-12-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2782133?pdf=render |