Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy

Activated microglia are an important type of innate immune cell in the brain, and they secrete inflammatory cytokines into the extracellular milieu, exert neurotoxicity to surrounding neurons and are involved in the pathogenesis of many brain disorders. Quercetin (Qu), a natural flavonoid, is known...

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Bibliographic Details
Main Authors: Xiaojuan Han, Tianshu Xu, Qijun Fang, Huajun Zhang, Lijun Yue, Gang Hu, Lingyun Sun
Format: Article
Published: Elsevier 2021-08-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721001683