Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells

Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells

Colorectal cancer (CRC) is the third most common malignancy and the fourth most common cause of cancer-related death worldwide. The treatment of metastatic CRC considered palliative for many years aiming for an improved life, with little hope of a cure, highlighting the need for developing novel tar...

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Bibliographic Details
Main Authors: S.M. Anisul Islam, Avijit Dey, Rekha Patel, Tracess Smalley, Mildred Acevedo-Duncan
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
CRC
DNA damage
Atypical PKC
Apoptosis
5-FU
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219352874

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http://www.sciencedirect.com/science/article/pii/S0753332219352874

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