Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection

Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection

In Alzheimer's disease (AD), astrocytes undergo morphological changes ranging from atrophy to hypertrophy, but the effect of such changes at the functional level is still largely unknown. Here, we aimed to investigate whether alterations in astrocyte activity in AD are transient and depend on t...

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Bibliographic Details
Main Authors: Tal Iram, Dorit Trudler, David Kain, Sivan Kanner, Ronit Galron, Robert Vassar, Ari Barzilai, Pablo Blinder, Zvi Fishelson, Dan Frenkel
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Neurobiology of Disease
Subjects:
Adult astrocyte culture
Alzheimer's disease
Neurotoxicity
Aβ uptake
SR-B1
VEGF
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116301930

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http://www.sciencedirect.com/science/article/pii/S0969996116301930

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