Mutant COMP shapes growth and development of skull and facial structures in mice and humans

Mutant COMP shapes growth and development of skull and facial structures in mice and humans

Abstract Background Cartilage oligomeric matrix protein (COMP) is an important extracellular matrix protein primarily functioning in the musculoskeletal tissues and especially endochondral bone growth. Mutations in COMP cause the skeletal dysplasia pseudoachondroplasia (PSACH) that is characterized...

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Bibliographic Details
Main Authors: Alexander Burger, Jasmien Roosenboom, Mohammad Hossain, Seth M. Weinberg, Jacqueline T. Hecht, Karen L. Posey
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
dwarfism
face
mutant cartilage oligomeric matrix protein
pseudoachondroplasia
skull
Online Access:https://doi.org/10.1002/mgg3.1251

Internet

https://doi.org/10.1002/mgg3.1251

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