Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression

Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression

Abstract Background Selective serotonin reuptaker inhibitors, including fluoxetine, are widely studied and prescribed antidepressants, while their exact molecular and cellular mechanism are yet to be defined. We investigated the involvement of HDAC1 and eEF2 in the antidepressant mechanisms of fluox...

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Bibliographic Details
Main Authors: Weifen Li, Tahir Ali, Chengyou Zheng, Zizhen Liu, Kaiwu He, Fawad Ali Shah, Qingguo Ren, Shafiq Ur Rahman, Ningning Li, Zhi-Jian Yu, Shupeng Li
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Neuroinflammation
Subjects:
Fluoxetine
Neuroinflammation
Depression
Synaptogenesis
HDAC1-eEF2
Online Access:https://doi.org/10.1186/s12974-021-02091-5

Internet

https://doi.org/10.1186/s12974-021-02091-5

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