Upregulation of Early and Downregulation of Terminal Pathway Complement Genes in Subcutaneous Adipose Tissue and Adipocytes in Acquired Obesity

Upregulation of Early and Downregulation of Terminal Pathway Complement Genes in Subcutaneous Adipose Tissue and Adipocytes in Acquired Obesity

Inflammation is an important mediator of obesity-related complications such as the metabolic syndrome but its causes and mechanisms are unknown. As the complement system is a key mediator of inflammation, we studied whether it is activated in acquired obesity in subcutaneous adipose tissue (AT) and...

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Bibliographic Details
Main Authors: Sanna Kaye, A. Inkeri Lokki, Anna Hanttu, Eija Nissilä, Sini Heinonen, Antti Hakkarainen, Jesper Lundbom, Nina Lundbom, Lilli Saarinen, Olli Tynninen, Maheswary Muniandy, Aila Rissanen, Jaakko Kaprio, Seppo Meri, Kirsi H. Pietiläinen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
obesity
complement system
gene expression
twin study
monozygotic twins
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00545/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00545/full

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