The genetically encoded tool set for investigating cAMP: more than the sum of its parts

Intracellular fluctuations of the second messenger cyclic AMP (cAMP) are regulated with spatial and temporal precision. This regulation is supported by the sophisticated arrangement of cyclases, phosphodiesterases, anchoring proteins and receptors for cAMP. Discovery of these nuances to cAMP signali...

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Bibliographic Details
Main Authors: Neha ePatel, Matthew G Gold
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Pharmacology
Subjects:
PKA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00164/full