Peroxiredoxin 2 oxidation reveals hydrogen peroxide generation within erythrocytes during high-dose vitamin C administration

Peroxiredoxin 2 oxidation reveals hydrogen peroxide generation within erythrocytes during high-dose vitamin C administration

Intravenous infusion of high dose (>10 g) vitamin C (IVC) is a common alternative cancer therapy. IVC results in millimolar levels of circulating ascorbate, which is proposed to generate cytotoxic quantities of H2O2 in the presence of transition metal ions. In this study we report on the in vitro...

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Bibliographic Details
Main Authors: Andree G. Pearson, Juliet M. Pullar, John Cook, Emma S. Spencer, Margreet CM. Vissers, Anitra C. Carr, Mark B. Hampton
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Redox Biology
Subjects:
Ascorbate
Haemoglobin
Hydrogen peroxide
Peroxiredoxin
Thiol oxidation
Erythrocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721001282

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http://www.sciencedirect.com/science/article/pii/S2213231721001282

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