Impact of ZBTB7A hypomethylation and expression patterns on treatment response to hydroxyurea

Impact of ZBTB7A hypomethylation and expression patterns on treatment response to hydroxyurea

Abstract Background We aimed to clarify the emerging epigenetic landscape in a group of genes classified as “modifier genes” of the β-type globin genes (HBB cluster), known to operate in trans to accomplish the two natural developmental switches in globin expression, from embryonic to fetal during t...

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Bibliographic Details
Main Authors: Vasiliki Chondrou, Eleana F. Stavrou, Georgios Markopoulos, Alexandra Kouraklis-Symeonidis, Vasilios Fotopoulos, Argiris Symeonidis, Efthymia Vlachaki, Panagiota Chalkia, George P. Patrinos, Adamantia Papachatzopoulou, Argyro Sgourou
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Human Genomics
Subjects:
SCA homozygotes
SCA/β-thal heterozygotes
Hydroxyurea treatment
HbF induction
HBB cluster “modifying genes”
Epigenetic regulation
Online Access:http://link.springer.com/article/10.1186/s40246-018-0177-z

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http://link.springer.com/article/10.1186/s40246-018-0177-z

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