Glutathione Supplementation Attenuates Lipopolysaccharide-induced Mitochondrial Dysfunction and Apoptosis in a Mouse Model of Acute Lung Injury

Glutathione Supplementation Attenuates Lipopolysaccharide-induced Mitochondrial Dysfunction and Apoptosis in a Mouse Model of Acute Lung Injury

Acute lung injury (ALI) is a life threatening condition associated with hypoxemia, diffuse alveolar damage, inflammation, and loss of lung function. Lipopolysaccharide (LPS; endotoxin) from the outer membrane of gram-negative bacteria is a major virulence factor involved in the development of ALI. T...

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Bibliographic Details
Main Authors: Saurabh eAggarwal, Christiana eDimitropoulou, Qing eLu, Stephen M Black, Shruti eSharma
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-05-01
Series:Frontiers in Physiology
Subjects:
Acute Lung Injury
Apoptosis
lipopolysaccharide
Mitochondrial dysfunction
Glutathione ethyl ester
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00161/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00161/full

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