Bayesian model selection techniques as decision support for shaping a statistical analysis plan of a clinical trial: An example from a vertigo phase III study with longitudinal count data as primary endpoint

Bayesian model selection techniques as decision support for shaping a statistical analysis plan of a clinical trial: An example from a vertigo phase III study with longitudinal count data as primary endpoint

<p>Abstract</p> <p>Background</p> <p>A statistical analysis plan (SAP) is a critical link between how a clinical trial is conducted and the clinical study report. To secure objective study results, regulatory bodies expect that the SAP will meet requirements in pre-spec...

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Bibliographic Details
Main Authors: Adrion Christine, Mansmann Ulrich
Format: Article
Language:English
Published: BMC 2012-09-01
Series:BMC Medical Research Methodology
Subjects:
Statistical analysis plan
Sensitivity analysis
Longitudinal count data
Bayesian generalized linear mixed models
INLA
Predictive performance
Bayesian model evaluation
Informed model choice
Online Access:http://www.biomedcentral.com/1471-2288/12/137

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http://www.biomedcentral.com/1471-2288/12/137

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