Boosting and lassoing new prostate cancer SNP risk factors and their connection to selenium

Abstract We begin by arguing that the often used algorithm for the discovery and use of disease risk factors, stepwise logistic regression, is unstable. We then argue that there are other algorithms available that are much more stable and reliable (e.g. the lasso and gradient boosting). We then prop...

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Bibliographic Details
Main Authors: David E. Booth, Venugopal Gopalakrishna-Remani, Matthew L. Cooper, Fiona R. Green, Margaret P. Rayman
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97412-2