2-Hydroxypropyl-β-cyclodextrin Regulates the Epithelial to Mesenchymal Transition in Breast Cancer Cells by Modulating Cholesterol Homeostasis and Endoplasmic Reticulum Stress

2-Hydroxypropyl-β-cyclodextrin Regulates the Epithelial to Mesenchymal Transition in Breast Cancer Cells by Modulating Cholesterol Homeostasis and Endoplasmic Reticulum Stress

Cholesterol metabolism affects endoplasmic reticulum (ER) stress and modulates epithelial-mesenchymal transition (EMT). Our previous study demonstrated that 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) attenuated EMT by blocking the transforming growth factor (TGF)-β/Smad signaling pathway and activatin...

Full description

Bibliographic Details
Main Authors: Yiyang Zhao, Linkang He, Tian Wang, Lifang Zhu, Nianlong Yan
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Metabolites
Subjects:
2-hydroxypropyl-β-cyclodextrin
cholesterol metabolism
endoplasmic reticulum stress
TGF-β/Smad signaling pathway
epithelial-mesenchymal transition
Online Access:https://www.mdpi.com/2218-1989/11/8/562

Internet

https://www.mdpi.com/2218-1989/11/8/562

Similar Items