Predicting HCC Response to Multikinase Inhibitors With In Vivo Cirrhotic Mouse Model for Personalized TherapySummary

Predicting HCC Response to Multikinase Inhibitors With In Vivo Cirrhotic Mouse Model for Personalized TherapySummary

Background & Aims: Hepatocellular carcinoma (HCC) arises in a cirrhotic, pro-angiogenic microenvironment. Inhibiting angiogenesis is a key mode of action of multikinase inhibitors and current non-cirrhotic models are unable to predict treatment response. We present a novel mouse cirrhotic mo...

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Bibliographic Details
Main Authors: Daniel Q. Huang, Mark D. Muthiah, Lei Zhou, Halisah Jumat, Wan Xin Tan, Guan Huei Lee, Seng Gee Lim, Alfred Kow, Glenn Bonney, Iyer Shridhar, Yi Ting Lim, Aileen Wee, Yin Huei Pang, Gwyneth Soon, Pierce Chow, Yock Young Dan
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Xenograft
Hepatocellular Carcinoma
Multikinase Inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X20302083

Internet

http://www.sciencedirect.com/science/article/pii/S2352345X20302083

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