USP36-Mediated Deubiquitination of DOCK4 Contributes to the Diabetic Renal Tubular Epithelial Cell Injury via Wnt/β-Catenin Signaling Pathway

USP36-Mediated Deubiquitination of DOCK4 Contributes to the Diabetic Renal Tubular Epithelial Cell Injury via Wnt/β-Catenin Signaling Pathway

Diabetic kidney disease (DKD) has become the leading cause of end-stage renal disease but the efficacy of current treatment remains unsatisfactory. The pathogenesis of DKD needs a more in-depth research. Ubiquitin specific proteases 36 (USP36), a member of deubiquitinating enzymes family, has arouse...

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Bibliographic Details
Main Authors: Suwei Zhu, Shaoshuai Hou, Yao Lu, Wei Sheng, Zhengguo Cui, Tianyi Dong, Hong Feng, Qiang Wan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ubiquitin specific proteases 36
dedicator of cytokinesis 4
Wnt/β-catenin
diabetic kidney disease
deubiquitination
epithelial-to-mesenchymal transition
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.638477/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.638477/full

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