Bcl2 deficiency activates FoxO through Akt inactivation and accelerates osteoblast differentiation.

Bcl2 deficiency activates FoxO through Akt inactivation and accelerates osteoblast differentiation.

Osteoblast apoptosis plays an important role in bone development and maintenance, and is in part responsible for osteoporosis in sex steroid deficiency, glucocorticoid excess, and aging. Although Bcl2 subfamily proteins, including Bcl2 and Bcl-XL, inhibit apoptosis, the physiological significance of...

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Bibliographic Details
Main Authors: Takeshi Moriishi, Yosuke Kawai, Hisato Komori, Satoshi Rokutanda, Yutaka Eguchi, Yoshihide Tsujimoto, Izumi Asahina, Toshihisa Komori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3896485?pdf=render

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http://europepmc.org/articles/PMC3896485?pdf=render

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