Lactate Limits T Cell Proliferation via the NAD(H) Redox State

Lactate Limits T Cell Proliferation via the NAD(H) Redox State

Summary: Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effector T cells. We report that nicotinamide adenine...

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Bibliographic Details
Main Authors: William J. Quinn, III, Jing Jiao, Tara TeSlaa, Jason Stadanlick, Zhonglin Wang, Liqing Wang, Tatiana Akimova, Alessia Angelin, Patrick M. Schäfer, Michelle D. Cully, Caroline Perry, Piotr K. Kopinski, Lili Guo, Ian A. Blair, Louis R. Ghanem, Michael S. Leibowitz, Wayne W. Hancock, Edmund K. Moon, Matthew H. Levine, Evgeniy B. Eruslanov, Douglas C. Wallace, Joseph A. Baur, Ulf H. Beier
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cell Reports
Subjects:
T cell metabolism
glycolysis
immunometabolism
nicotinamide adenine dinucleotide
lactate metabolism
3-phosphoglycerate
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720314893

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http://www.sciencedirect.com/science/article/pii/S2211124720314893

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