Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations

Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations

Absence seizures result from 3 to 5 Hz generalized thalamocortical oscillations that depend on highly regulated inhibitory neurotransmission in the thalamus. Efficient reuptake of the inhibitory neurotransmitter GABA is essential, and reuptake failure worsens human seizures. Here, we show that block...

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Bibliographic Details
Main Authors: Adam C Lu, Christine Kyuyoung Lee, Max Kleiman-Weiner, Brian Truong, Megan Wang, John R Huguenard, Mark P Beenhakker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
T-type calcium channel
GABAB receptor
thalamic networks
thalamocortical neuron
GABA transporter
network oscillations
Online Access:https://elifesciences.org/articles/59548

Internet

https://elifesciences.org/articles/59548

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