Mutation-Structure-Function Relationship Based Integrated Strategy Reveals the Potential Impact of Deleterious Missense Mutations in Autophagy Related Proteins on Hepatocellular Carcinoma (HCC): A Comprehensive Informatics Approach

Mutation-Structure-Function Relationship Based Integrated Strategy Reveals the Potential Impact of Deleterious Missense Mutations in Autophagy Related Proteins on Hepatocellular Carcinoma (HCC): A Comprehensive Informatics Approach

Autophagy, an evolutionary conserved multifaceted lysosome-mediated bulk degradation system, plays a vital role in liver pathologies including hepatocellular carcinoma (HCC). Post-translational modifications (PTMs) and genetic variations in autophagy components have emerged as significant determinan...

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Bibliographic Details
Main Authors: Faryal Mehwish Awan, Ayesha Obaid, Aqsa Ikram, Hussnain Ahmed Janjua
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:International Journal of Molecular Sciences
Subjects:
autophagy related proteins
missense single nucleotide polymorphisms
post-translational modifications
hepatocellular carcinoma
computational analysis
Online Access:http://www.mdpi.com/1422-0067/18/1/139

Internet

http://www.mdpi.com/1422-0067/18/1/139

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