A Drosophila model of myeloproliferative neoplasm reveals a feed-forward loop in the JAK pathway mediated by p38 MAPK signalling

A Drosophila model of myeloproliferative neoplasm reveals a feed-forward loop in the JAK pathway mediated by p38 MAPK signalling

Myeloproliferative neoplasms (MPNs) of the Philadelphia-negative class comprise polycythaemia vera, essential thrombocythaemia and primary myelofibrosis (PMF). They are associated with aberrant numbers of myeloid lineage cells in the blood, and in the case of overt PMF, with development of myelofibr...

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Bibliographic Details
Main Authors: Ana Terriente-Félix, Lidia Pérez, Sarah J. Bray, Angel R. Nebreda, Marco Milán
Format: Article
Language:English
Published: The Company of Biologists 2017-04-01
Series:Disease Models & Mechanisms
Subjects:
JAK
p38 MAPK
Myeloproliferative neoplasm
Haemocyte
Hypertrophy
Drosophila
Online Access:http://dmm.biologists.org/content/10/4/399

Internet

http://dmm.biologists.org/content/10/4/399

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