A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas.

A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas.

Pheochromocytomas are neural crest-derived tumors that arise from inherited or sporadic mutations in at least six independent genes. The proteins encoded by these multiple genes regulate distinct functions. We show here a functional link between tumors with VHL mutations and those with disruption of...

Full description

Bibliographic Details
Main Authors: Patricia L M Dahia, Ken N Ross, Matthew E Wright, César Y Hayashida, Sandro Santagata, Marta Barontini, Andrew L Kung, Gabriela Sanso, James F Powers, Arthur S Tischler, Richard Hodin, Shannon Heitritter, Francis Moore, Robert Dluhy, Julie Ann Sosa, I Tolgay Ocal, Diana E Benn, Deborah J Marsh, Bruce G Robinson, Katherine Schneider, Judy Garber, Seth M Arum, Márta Korbonits, Ashley Grossman, Pascal Pigny, Sérgio P A Toledo, Vania Nosé, Cheng Li, Charles D Stiles
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2005-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1183527?pdf=render

Internet

http://europepmc.org/articles/PMC1183527?pdf=render

Similar Items