A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas.
Pheochromocytomas are neural crest-derived tumors that arise from inherited or sporadic mutations in at least six independent genes. The proteins encoded by these multiple genes regulate distinct functions. We show here a functional link between tumors with VHL mutations and those with disruption of...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2005-07-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC1183527?pdf=render |