A Brain Signaling Framework for Stress-Induced Depression and Ketamine Treatment Elucidated by Phosphoproteomics

A Brain Signaling Framework for Stress-Induced Depression and Ketamine Treatment Elucidated by Phosphoproteomics

Depression is a common affective disorder characterized by significant and persistent low mood. Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, is reported to have a rapid and durable antidepressant effect, but the mechanisms are unclear. Protein phosphorylation is a post-translationa...

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Bibliographic Details
Main Authors: Yan Xiao, Huoqing Luo, Wen Z. Yang, Yeting Zeng, Yinbo Shen, Xinyan Ni, Zhaomei Shi, Jun Zhong, Ziqi Liang, Xiaoyu Fu, Hongqing Tu, Wenzhi Sun, Wei L. Shen, Ji Hu, Jiajun Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
depression
chronic unpredictable mild stress (CUMS)
ketamine
LC-MS/MS
phosphoproteomics
brain signaling
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00048/full

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https://www.frontiersin.org/article/10.3389/fncel.2020.00048/full

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