FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice

FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice

Pathological neovascularization, a leading cause of blindness, is seen in retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration. Using a mouse model of hypoxia-driven retinal neovascularization, we find that fibroblast growth factor 21 (FGF21) administration suppress...

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Bibliographic Details
Main Authors: Zhongjie Fu, Yan Gong, Raffael Liegl, Zhongxiao Wang, Chi-Hsiu Liu, Steven S. Meng, Samuel B. Burnim, Nicholas J. Saba, Thomas W. Fredrick, Peyton C. Morss, Ann Hellstrom, Saswata Talukdar, Lois E.H. Smith
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Subjects:
retinal neovascularization
hypoxia
oxygen-induced retinopathy
choroidal neovascularization
FGF21
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717300463

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http://www.sciencedirect.com/science/article/pii/S2211124717300463

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