Regulating factors of PrP glycosylation in Creutzfeldt-Jakob disease--implications for the dissemination and the diagnosis of human prion strains.

<h4>Objective</h4>The glycoprofile of pathological prion protein (PrP(res)) is widely used as a diagnosis marker in Creutzfeldt-Jakob disease (CJD) and is thought to vary in a strain-specific manner. However, that the same glycoprofile of PrP(res) always accumulates in the whole brain of...

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Main Authors: Etienne Levavasseur, Isabelle Laffont-Proust, Emilie Morain, Baptiste A Faucheux, Nicolas Privat, Katell Peoc'h, Véronique Sazdovitch, Jean-Philippe Brandel, Jean-Jacques Hauw, Stéphane Haïk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-07-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18665216/pdf/?tool=EBI