Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α

Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α

Adolescents are particularly vulnerable to nicotine, the principal addictive component driving tobacco smoking. In a companion study, we found that reduced activity of the translation initiation factor eIF2α underlies the hypersensitivity of adolescent mice to the effects of cocaine. Here we report...

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Bibliographic Details
Main Authors: Andon N Placzek, David L Molfese, Sanjeev Khatiwada, Gonzalo Viana Di Prisco, Wei Huang, Carmela Sidrauski, Krešimir Krnjević, Christopher L Amos, Russell Ray, John A Dani, Peter Walter, Ramiro Salas, Mauro Costa-Mattioli
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
nicotine-induced plasticity
protein synthesis
ventral tegmental area
human fMRI
adolescents
Online Access:https://elifesciences.org/articles/12056

Internet

https://elifesciences.org/articles/12056

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