Interferon Regulatory Factor 4 Regulates the Development of Polymorphonuclear Myeloid-Derived Suppressor Cells Through the Transcription of c-Myc in Cancer

Interferon Regulatory Factor 4 Regulates the Development of Polymorphonuclear Myeloid-Derived Suppressor Cells Through the Transcription of c-Myc in Cancer

The accumulation of myeloid-derived suppressor cells (MDSCs) is one of the major obstacles to achieve an appropriate anti-tumor immune response and successful tumor immunotherapy. MDSCs in tumor-bearing hosts are primarily polymorphonuclear (PMN-MDSCs). However, the mechanisms regulating the develop...

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Bibliographic Details
Main Authors: Quan Yang, Hongyan Xie, Xing Li, Yuanfa Feng, Shihao Xie, Jiale Qu, Anqi Xie, Yiqiang Zhu, Lu Zhou, Jinxue Yang, Xiaohao Hu, Haixia Wei, Huaina Qiu, Wenjuan Qin, Jun Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
interferon regulatory factor 4 (IRF4)
myeloid-derived suppressor cells (MDSCs)
c-Myc
immunosuppression
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.627072/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.627072/full

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