Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton

Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton

Light-based modulation of the microtubule (MT) cytoskeleton is an attractive goal for spatiotemporally-resolved MT studies. Here the authors develop a first generation photoswitchable small molecule MT stabiliser based on paclitaxel, allowing optical control over cellular MT dynamics.

Bibliographic Details
Main Authors: Adrian Müller-Deku, Joyce C. M. Meiring, Kristina Loy, Yvonne Kraus, Constanze Heise, Rebekkah Bingham, Klara I. Jansen, Xiaoyi Qu, Francesca Bartolini, Lukas C. Kapitein, Anna Akhmanova, Julia Ahlfeld, Dirk Trauner, Oliver Thorn-Seshold
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18389-6

Internet

https://doi.org/10.1038/s41467-020-18389-6

Similar Items