Propensity for somatic expansion increases over the course of life in Huntington disease

Propensity for somatic expansion increases over the course of life in Huntington disease

Recent work on Huntington disease (HD) suggests that somatic instability of CAG repeat tracts, which can expand into the hundreds in neurons, explains clinical outcomes better than the length of the inherited allele. Here, we measured somatic expansion in blood samples collected from the same 50 HD...

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Bibliographic Details
Main Authors: Radhia Kacher, François-Xavier Lejeune, Sandrine Noël, Cécile Cazeneuve, Alexis Brice, Sandrine Humbert, Alexandra Durr
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-05-01
Series:eLife
Subjects:
Huntington disease
HD mutation carrier
somatic instability
longitudinal study
human data
CAG expansion
Online Access:https://elifesciences.org/articles/64674

Internet

https://elifesciences.org/articles/64674

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