Stimulation of the Internal Ribosome Entry Site (IRES)-Dependent Translation of Enterovirus 71 by DDX3X RNA Helicase and Viral 2A and 3C Proteases

Stimulation of the Internal Ribosome Entry Site (IRES)-Dependent Translation of Enterovirus 71 by DDX3X RNA Helicase and Viral 2A and 3C Proteases

The translation of enterovirus 71 (EV71) is mediated by an internal ribosome entry site (IRES)-dependent manner. EV71 IRES comprises five highly structured domains (domains II-VI) in the 5′-untranslated region of the viral mRNA. A conserved AUG triplet residing in domain VI is proposed to be the rib...

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Bibliographic Details
Main Authors: Yu-Siang Su, Ai-Hsuan Tsai, Yueh-Feng Ho, Shin-Yi Huang, Yen-Chun Liu, Lih-Hwa Hwang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Microbiology
Subjects:
enterovirus
internal ribosome entry site (IRES)
DDX3X
RNA helicase
viral protease
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01324/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01324/full

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