Pyrvinium Treatment Confers Hepatic Metabolic Benefits via β-Catenin Downregulation and AMPK Activation

Pyrvinium Treatment Confers Hepatic Metabolic Benefits via β-Catenin Downregulation and AMPK Activation

Genetic evidence has indicated that β-catenin plays a vital role in glucose and lipid metabolism. Here, we investigated whether pyrvinium, an anthelmintic agent previously reported as a down-regulator of cellular β-catenin levels, conferred any metabolic advantages in treatment of metabolic disorder...

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Bibliographic Details
Main Authors: Shiwei Zhou, Obinna N. Obianom, Jiangsheng Huang, Dong Guo, Hong Yang, Qing Li, Yan Shu
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceutics
Subjects:
pyrvinium
beta catenin
AMPK activation
gluconeogenesis
lipid metabolism
Online Access:https://www.mdpi.com/1999-4923/13/3/330

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https://www.mdpi.com/1999-4923/13/3/330

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