Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain

Histone acetylation is an epigenetic modification that plays a critical role in chromatin remodelling and transcriptional regulation. There is increasing evidence that epigenetic modifications may become compromised in aging and increase susceptibility to the development of neurodegenerative disorde...

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Bibliographic Details
Main Authors: Pritika J. Narayan, Claire Lill, Richard Faull, Maurice A. Curtis, Mike Dragunow
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003696