Linezolid Trough Concentrations Correlate with Mitochondrial Toxicity-Related Adverse Events in the Treatment of Chronic Extensively Drug-Resistant Tuberculosis

Linezolid Trough Concentrations Correlate with Mitochondrial Toxicity-Related Adverse Events in the Treatment of Chronic Extensively Drug-Resistant Tuberculosis

Long-term linezolid use is limited by mitochondrial toxicity-associated adverse events (AEs). Within a prospective, randomized controlled trial of linezolid to treat chronic extensively drug-resistant tuberculosis, we serially monitored the translational competence of mitochondria isolated from peri...

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Bibliographic Details
Main Authors: Taeksun Song, Myungsun Lee, Han-Seung Jeon, Yumi Park, Lori E. Dodd, Véronique Dartois, Dean Follman, Jing Wang, Ying Cai, Lisa C. Goldfeder, Kenneth N. Olivier, Yingda Xie, Laura E. Via, Sang Nae Cho, Clifton E. Barry III, Ray Y. Chen
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:EBioMedicine
Subjects:
Mitochondrial toxicity
Adverse events
Linezolid
Tuberculosis
Drug resistant
Therapeutic drug monitoring
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415301663

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http://www.sciencedirect.com/science/article/pii/S2352396415301663

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