Proteomics Investigation of the Time Course Responses of RAW264.7 Macrophages to Infections With the Wild-Type and Twin-Arginine Translocation Mutant Strains of Brucella melitensis

Proteomics Investigation of the Time Course Responses of RAW264.7 Macrophages to Infections With the Wild-Type and Twin-Arginine Translocation Mutant Strains of Brucella melitensis

Brucella, a notorious intracellular pathogen, causes chronic infections in many mammals, including humans. The twin-arginine translocation (Tat) pathway transports folded proteins across the cytoplasmic membrane; protein substrates translocated by Brucella include ABC transporters, oxidoreductases,...

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Bibliographic Details
Main Authors: Xin Yan, Sen Hu, Yan Yang, Da Xu, Wenxing Liu, Ganwu Li, Wentong Cai, Zhigao Bu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Brucella melitensis
twin-arginine protein translocation
immune response
RAW264.7 cell model
cytokines
nitric oxide - NO
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.679571/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.679571/full

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