Bu-Shen-Huo-Xue Decoction Ameliorates Diabetic Nephropathy by Inhibiting Rac1/PAK1/p38MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Mice

Bu-Shen-Huo-Xue Decoction Ameliorates Diabetic Nephropathy by Inhibiting Rac1/PAK1/p38MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Mice

Diabetic nephropathy (DN), a leading cause of end-stage renal disease, is associated with high morbidity and mortality rates worldwide and the development of new drugs to treat DN is urgently required. Bu-Shen-Huo-Xue (BSHX) decoction is a traditional Chinese herbal formula, made according to tradit...

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Bibliographic Details
Main Authors: Weisong Wang, Hongping Long, Wei Huang, Ting Zhang, Lihua Xie, Cheng Chen, Jianhe Liu, Dan Xiong, Wei Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
diabetic nephropathy
Bu-Shen-Huo-Xue decoction
podocyte epithelial-mesenchymal transition
Rac1
PAK1
p38MAPK
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.587663/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.587663/full

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