CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica

CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica

Abstract Background Neuromyelitis optica spectrum disorder (herein called NMO) is an inflammatory demyelinating disease that can be initiated by binding of immunoglobulin G autoantibodies (AQP4-IgG) to aquaporin-4 on astrocytes, causing complement-dependent cytotoxicity (CDC) and downstream inflamma...

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Bibliographic Details
Main Authors: Lukmanee Tradtrantip, Tianjiao Duan, Michael R. Yeaman, Alan S. Verkman
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Neuroinflammation
Subjects:
NMO
Aquaporin-4
CD55
Astrocyte
Complement-dependent cytotoxicity
Statins
Online Access:http://link.springer.com/article/10.1186/s12974-019-1448-x

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http://link.springer.com/article/10.1186/s12974-019-1448-x

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