Icariin Prevents Extracellular Matrix Accumulation and Ameliorates Experimental Diabetic Kidney Disease by Inhibiting Oxidative Stress via GPER Mediated p62-Dependent Keap1 Degradation and Nrf2 Activation

Icariin Prevents Extracellular Matrix Accumulation and Ameliorates Experimental Diabetic Kidney Disease by Inhibiting Oxidative Stress via GPER Mediated p62-Dependent Keap1 Degradation and Nrf2 Activation

The present study aimed to determine whether icariin could attenuate type 1 diabetic nephropathy (T1DN) induced by streptozotocin (STZ) after 4 weeks or not. Therefore, its therapeutic effect on diabetic kidney disease was investigated in view of reactive oxygen (ROS) and extracellular matrix (ECM)...

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Bibliographic Details
Main Authors: Kai Wang, Xiulan Zheng, Zhenzhen Pan, Wenhui Yao, Xin Gao, Xiniao Wang, Xuansheng Ding
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
diabetic kidney disease
icariin
oxidative stress
extracellular matrix
GPER
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00559/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.00559/full

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