Characterization of a novel OTX2‐driven stem cell program in Group 3 and Group 4 medulloblastoma

Characterization of a novel OTX2‐driven stem cell program in Group 3 and Group 4 medulloblastoma

Medulloblastoma (MB) is the most common malignant primary pediatric brain cancer. Among the most aggressive subtypes, Group 3 and Group 4 originate from stem/progenitor cells, frequently metastasize, and often display the worst prognosis, yet we know the least about the molecular mechanisms driving...

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Bibliographic Details
Main Authors: Margaret Stromecki, Nazanin Tatari, Ludivine Coudière Morrison, Ravinder Kaur, Jamie Zagozewski, Gareth Palidwor, Vijay Ramaswamy, Patryk Skowron, Matthias Wölfl, Till Milde, Marc R. Del Bigio, Michael D. Taylor, Tamra E. Werbowetski‐Ogilvie
Format: Article
Language:English
Published: Wiley 2018-04-01
Series:Molecular Oncology
Subjects:
axon guidance genes
medulloblastoma
orthodenticle homeobox 2
RHO
semaphorin
stem cells
Online Access:https://doi.org/10.1002/1878-0261.12177

Internet

https://doi.org/10.1002/1878-0261.12177

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